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Effect of combination of Doxycycline and Minocycline antibiotic on Ketamine induced experimental Schizophrenia in mice

Sher Singh*, Deepa Khanna, Rampal Singh Negi and Sanjeev Kalra


Schizophrenia is a complex, chronic and widespread psychiatric problem that affects about 1% of the world’s total population. The risk of developing Schizophrenia is about the same for men and women, but there are gender differences in the development of the disease. Doxycycline and Minocycline are tetracyclines with potent antioxidant, anti-inflammatory, immunomodulatory, neuroprotective, antidepressant, anti-anxiety, antipsychotic, memory enhancing, neuroprotective properties and better pharmacokinetic profile. This tetracycline is used to treat psychosis and to evaluate its protective effects against Ketamine-induced behavioral, biochemical, neurochemical and histological changes in mice. Olanzapine is a drug that acts on the brain to treat Schizophrenia. Olanzapine restores the balance of Dopamine and Serotonin, which improves thinking, mood and behavior.
Results: In the present study, pretreatment with a combination of Doxycycline and Minocycline was studied for Ketamine-induced psychosis in mice. Pretreatment with the combination of Doxycycline and Minocycline showed valuable antipsychotic activity that would be exploited due to its antibiotic activity. Combination of the two antibiotics ameliorated behavioural changes as represented by hyper locomotion and stereotype behavior, increased immobility, increased step down latency on 7th, 14th and 21st day respectively. Further the combination showed biochemical, neurochemical and histological changes as assessed on 22nd day.
Conclusion: The results indicate that the combination of Doxycycline and Minocycline may be a new option for the treatment of Ketamine-induced psychotic symptoms in animal models. The combination of Doxycycline and Minocycline has been shown to be more effective than monotherapy in the treatment of the positive, negative and cognitive symptoms of Ketamine-induced Schizophrenia. GABAnergic, antioxidant, anti-inflammatory, acetyl cholinesterase inhibition exhibited by these antibiotics probably be mechanisms involved in the treatment of psychosis.

Keywords: Schizophrenia, Doxycycline, Minocycline, Olanzapine, Ketamine.

Posted in Volume 4, Issue No. 2 (April-June 2022)

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