https://doi.org/10.51514/JSTR.3.4.2021.16-23
Sher Singh*, Priyanka and Deepa Khanna
ABSTRACT
Background: Obsessive compulsive disorder (OCD) is a disabling and common neuropsychiatric condition of poorly known etiology. Many attempts have been made in the last few years to develop animal models of OCD with the aim of clarifying the genetic, neurochemical, and neuroanatomical basis of the disorder, as well as of developing novel pharmacological and neurosurgical treatments that may help to improve the prognosis of the illness. The latter goal is particularly important given that around 40% of patients with OCD do not respond to currently available therapies. OCD is a mental disorder in which alteration of brain neurotransmitters take place and these alterations applicable for producing. Comprehensive search reveals that people with schizophrenia seem like they have lost contact with reality and remitting disorder associated with significant impairments in social, vocational functioning and shortened lifespan.
Objective: Many efforts have been made in the last few years to develop animal models of OCD with the objective of clarifying the genetic, neurochemical, and neuroanatomical basis of the disorder
Methods: These types of animal behavior models are introduced for evaluation of OCD symptoms and furthermore it’s a good approach before going on clinical studies in human participants. Throughout the review article various animal models used for the determining the OCD symptoms.
Result: OCD can be complicated and hard to understand. It can be difficult to recognize in both children and adults. However, there is always hope for a better life free from OCD. A number of animal behavioral models such as genetic model, pharmacological model, behavioral model, neurodevelopmental model in mice were compiled in this review for easy learning or assessing behavioral parameters of OCD.
Conclusion: In the previous clinical or preclinical studies symptoms like Marble-burying, anxiety, and repetitive gnawing behavior are seen in OCD affected people. Moreover, symptoms are assessed by conducting behavioral, biochemical and neurochemical estimation on rodent/human trial. Animal models have been based on the management of behavioral parameters believed to be involved in OCD. This review provides a brief overview of behavioral animals models used for the diagnosis of OCD.
Keywords: obsessive compulsive disorder, genetic model, pharmacological model, behavioral model and
neurodevelopmental model.