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Assessment of Toxicity of Aluminum Fluoride On Some Selected Heamatological Parameters of Male Wistar Rats

Dharmendra Pratap Singh and Kusum Kushwah*


Aluminum fluoride has the potential to improve the bioavailability of water to humans. The elimination of aluminum from the body is extremely slow [Varner et al., (1994)]. The half-life of total body aluminum was estimated to be 7 years for humans and reflects the redistribution of bone reserves. (Yokel et al., 2001). Aluminum may be a neurotoxin at levels as low as 00.08 ppm (Hewitt et al., 1990) and also has an impact on hematology (Turgut et al., 2007). The relationship between fluoride and aluminum and their effects on hematological parameters is a concern that has not been extensively investigated. There were 30 male rats in this study. Fifteen who were used because the treatment group was given a combination of aluminum fluoride. Treatment of mice with aluminum fluoride (AIF3, 200 mg/kg body weight/day) for 30 days caused marked hematological changes within the Erythrocyte Sedimentation Rate (ESR), Mean Corpuscular Volume (MCV), Mean Corpuscular Heamoglobin (MCH) and mean Corpuscular Hemoglobin Concentration (MCHC). Result also observed that very same hematological parameters decreased levels of MCH and MCHC and increase level of ESR and MCV. The rise in ESR and MCV are significant. Our determinations on AIF3 revealed that several toxic effects on animal heamatology.

Keywords: Aluminum Fluoride, ESR, MCV, MCH, MCHC.

Posted in Volume 3, Issue No. 4 (October-December 2021)

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