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Optical Recording of Neural Activity Using A Focused Ion Beam Milled Fiber Optic Fabry-Perot

Mohammad Ismail Zibaii*, Azam Layeghi, Leila Dargahi, Abbas Haghparast and Orlando Frazao


A Fabry-Perot cavity milled with a focused ion beam on a tapered fiber tip is proposed for in vivo neural activity recording as an optical method. Optical fiber micro-tips are good candidate devices for sensing applications in a small volume and difficult to access locations, such as neuroscience research. The fiber-based probe is electrical artifact-free, labeling free, and feasible for a portable system compared with conventional in vivo neural recording networks. Optical signals and electrical neural activity from the rat somatosensory cortex were simultaneously recorded. This fiber-based probe promises the enhanced ability to .extracellular recording of the neural activity in neurophotonics applications. It has a potential capability compared with optrode in optogenetics techniques. Therefore, a single fiber optic probe can be used for simultaneous optical stimulation and optical recording.

Keywords: Neuron, optical recording, single-unit recording, tapered fiber tip, milled Fabry Perot, refractive index, ion channel

Posted in Issue No. 4 (October-December 2020), Volume 2