https://doi.org/10.51514/JSTR.5.4.2023.9-16
Kusum Kushwah, Akansha Rao, and Dharmendra Pratap Singh
ABSTRACT
Aloe Vera is used both packaged and traditionally commercially in earth numerous regions of the for many cosmetic and soothing purposes. The present study was carried out to observe the protective effect of Aloevera plant on aluminium fluoride induced deterioration changes in kidney of albino rats. Aloevera is herbal/medicinal plant attached to the family liliaceae which has a large range of curative applications such as curing ulcers; wound healing, burns, diabetes for easing intestinal, arthritic swellings and curing. Aluminium fluoride is toxic metals are universally found in environment human and animals are exposed to them by water, food, soil and contaminated Al (Aluminium) attachments to this group of harmful (toxic) metals. It is the 3 most familiar element in the world’s crust and is everywhere in the environment yet, its biochemical and biological functions still remaining unknown. The target tissues for Al burden are brain, bone, kidney and liver symptoms and signs include dementia, esophagitis, colic, gastro enteritis, liver and kidney damage. Fluoride (F) toxicity is most serious health issue in human being and animals (rats). The drinking water restrains more than 1-1.5ppm of F. Fluoride is quickly absorbed from the by the gastrointestinal tract after oral administration. Exposure of fluoride in big and small amount for small time and for long duration causes toxic effects in some target objective organs like kidney, liver, blood and others organs. This study focused on estimation of the safety of Aloevera on kidney parameters-creatinine, uric acid, urea, sodium, potassium and BUN (blood urea nitrogen). Sixty albino rats were randomly and equally divided into three groups for 30 and 60 days consecutively. The first group served as control group for the experiment and second group treated with aluminium fluoride (200mg/kg b.w.) and third group treated with AlF3 along with Aloevera (300mgg/kg b.w.). Blood samples were collected on day 31st and 61stto determined changes in the kidney function for toxicity. Above parameters significantly increased treated with AlF3. The outcomes of this study suggested that Aloevera was effective in shorting AlF3 toxicity in kidney. Hence, Aloevera gel and its active compound (aloin) can be used as adjuvant therapy for the curative roll of Aluminium fluoride induced renal damage.
Keywords: Kidney, Aloevera, Aluminium fluoride, Albino rat and Biochemical parameters.